The true origin of Alzheimer and its definitive cure
Distortion of the conscious attention mechanism.
By: José de Jesús Tejada Maury (*)
"If science is practiced without love, the human feeling that characterizes it is lost" (José Tejada Maury).
When a researcher takes the job to approach any problem whatever and about which the academy does not know its true origin, the first thing that is done is to detect the faults on why a correct scientific explanation has not been found. There is a lack of coordination between the interdisciplinary teams to try to find not only the explanation of the phenomenon or the problem, that is to say; Its causality, therefore, is to seek de fac to the solution to the problem, because precisely the cause or reason why the solution is not found is due to the inadequate interpretation of the problem.
Diluously neurologists have been working on one hand and on the other the experts in biochemistry, very possibly this has become a hindrance to the solution of the problem, to which is combined the lack of initiative and creativity to typify the condition, it is to say, the first step that neurology and its interdisciplinary team must have defined is not having considered scientifically itself, that is an idea as such, it has essentially had to consider the idea as a fluid, as electrical signal of the brain that is originated by the thought, to be able to understand why the ideas of association are not being formed that allow the relationship between: consciousness, keepsake and memory, because if a person says or affirms that he lost his memory, then some will ask themselves why does that person remember facts from his past life? Therefore, he has not lost his memory (memory is the faculty of remembrance).
Both neurology and biochemistry have ignored that ideas are peptides and that is the initial phase with which the problem has had to be addressed as soon as the formation of senile plaques or proteins was detected through laboratory analysis. Beta-amyloid and the intracellular formation of neurofibrillary tangles of Tau protein.
In the case of people who do not recognize their relatives or some present circumstances, but they do remember past events (memory-remembrance), the indication focuses on the mechanism of present attention, which gives us to presume that the initial phase of the attention mechanism to assimilate and form the present ideas of association is unstructured.
The act or operation of memory is called remembering, remembering something supposes first having experienced that something, which belongs to perception, implies secondly the conservation of sensations and ideas that something aroused in us, and in third place the reappearance or memory itself at a later time of our existence of these ideas or sensations and finally their recognition as past, regardless of the first stage that is not specific to memory but to perception (sensory knowledge), memory it comes to be constituted by three actors or successive stages: conservation, reappearance and recognition. If the conservation and reproduction is suppressed, the memory is annulled, if the location in the past is suppressed, the memory ceases to exist in itself.
The scene of events:
There is a system in charge of governing the organized function of our apparatuses that is the nervous system (SN), which captures the external stimuli by means of receptors, translates them into electrical impulses that leads to the central nervous system (CNS), through of a system of conductors (nerves), and thus, the SNC elaborates a response sent by the nerves and carried out by other systems in response to the stimulus. We can infer that one of the functions of the amyloid protein is to be a receptor and contact bridge to transfer signals to the central nervous system. The central nervous system (CNS) is made up of the brain and the spinal cord, both composed of millions of specialized cells called neurons, arranged in an orderly fashion and communicated with each other and with effectors by means of extensions called axons and dendrites. The neurons are arranged inside a framework with non-nervous cells, which together are called neuroglia.
The central nervous system is protected by bone envelopes and membranous sheaths.
The bony sheaths are the skull and spine. The membranous sheaths, collectively called meninges, are called dura, arachnoid, and pia mater.
The peripheral nervous system is composed of all the nerves that start from the central nervous system and branch out to reach all parts of the body. There are two types of nerves: cranial nerves andspinal.
The cranial, are directly connected to the brain, are twelve pairs and belong to the eyes, ears, nose, palate and tongue and touch (this cranial nerve has motor, sensory and sensory functions). These nerves allow the instantaneous transmission to the brain of what we see, hear, smell, and taste or touch. They send warnings about dangers that we face and this allows the brain to respond immediately and send orders to act and protect us. In the deconstruction of the amyloid protein the mechanism of reception of immediate stimuli of the cranial nerves such as sight, hearing, smell, taste and touch is deteriorated.
Spinal Nerves: the 31 pairs of spinal nerves leave the spinal cord towards the right and left of our body, form large and organized work teams that perform different tasks such as making the heart, lungs, skin and all the rest of the body work.
The spinal nerves also form another system, the nervous skeleton responsible for controlling all the voluntary muscular movements, that is to say those that we do when we want, like walking, running, writing or chewing.
The cranial nerves and spinals work in coordination so that the body can react quickly. For example, the cranial nerves of sight, hearing, smell, taste and touch send some warning signs and the spinals act quickly so that we react by protecting ourselves from danger.
The difference between the central nervous system (CNS) and the peripheral nervous system (SNP) is that the peripheral nervous system is not protected by bones or by the blood-brain barrier, which is located between the CNS and blood vessels and prevents many toxic substances from leaving. In general, the peripheral nervous system (PNS) coordinates, regulates and integrates our internal organs by means of involuntary responses.
It is important to keep in mind the relationship between the cranial nerves and the spinal nerves since at the end of the article they will better understand why the procedures applied by modern pharmacology (glutamate inhibitors) are leading the patient to a deplorable state.
Amnesia is the pathological forgetfulness of our memories and should not be confused with the normal forgetfulness that comes to be a prerequisite to the exercise of memory, here , the mnemonic exercises work and not the supposed exercises to prevent Alzheimer. It is at this point that any supposed exercise to prevent Alzheimer is questioned, since a mnemonic exercise is adequate to exercise memory, but it does not work when there may be factors other than the purpose of the mnemonic exercise, therefore; for this case we are facing a condition of physiological origin, while for mnemonics the mechanism of structuring ideas for conscious attention is preserved, for Alzheimer the mechanism of formation of ideas for conscious attention is being deconstructed. Make specific clarities, therefore mental exercises to prevent Alzheimer are a myth.
Aspects to consider in the study of Alzheimer:
The case of short-term memory, the regardings will remain in the prefrontal part of the brain and to save the memory of long-term memories is the hippocampus.
Neurons are cells that are part of the nervous system, the most basic functions of neurons are to receive information and transmit it through electrical impulses along large communication networks throughout the nervous system.
For the understanding of Alzheimer we must understand that ideas (peptides) are electrical signals results of an interaction of biochemical reactions at cerebral level, that is to say; the ideas are electrical impulses coming from chemical reactions that through the consciousness acquire the configuration as such, can be through mental images and then through mechanism of association (effect of neurotransmitters) are contextualized to interpret them through the organs of senses, either in written form orally, or in gesticulations (for the case of the disabled).
Although the study of Alois Alzheimer, who was the one who discovered the formation of senile neurofibrils, although currently according to the academia, it is not completely known what are the causes of Alzheimer and why it occurs. In the brains of people affected by Alzheimer's disease have been identified abnormal deposits of two proteins that form aggregates and inclusions, deconstructing the brain architecture. These proteins are called Beta-amyloid and the intracellular formation of neurofibrillary tangles of tau protein. The amyloid precursor protein (PPA) denatures and cakes forming insoluble aggregates between brain cells, these aggregates are only visible under the microscope are called senile plaques or amyloid plaques, is a process of denaturation that undergoes the amyloid protein and tau protein.
It is precisely the denaturing process of the protein where the origin of the problem lies, therefore it is at this point where it arises the first question about why amyloid protein and tau are denatured and here begins the analysis for both neurology and biochemistry.
According to biochemistry, there is only one mechanism for a protein to denature and is by alkalizing or acidifying the protein. liquid medium that surrounds proteins, for our study we specifically refer to the extracellular fluid that in this case corresponds to the cerebrospinal fluid and it is the physiochemical conditions of the cerebrospinal fluid that are affecting the synthesis of proteins at the level of neuronal cells, such as it was mentioned earlier the ideas are peptide s. The acid-base behavior of the peptides since they have a terminal amino group and a carboxyl terminal can have ionizable R groups, the peptides have an acidic behavior -base similar to amino acids. (See function of cerebrospinal fluid in the vocabulary of this article).
Peptides, like amino acids and proteins are biomolecules with an amphoteric character that allow the homeostatic regulation of organisms.
It is to highlight this behavior in enzymes, peptides that they function as biological catalysts for metabolic reactions since they have an ability to function within certain Ph levels. If they are overcome, a decompensation of charges occurs on the surface of the enzyme, which loses its structure and function (denatures). , and this is precisely what happens with amyloid and tau, which is denatured and is the cause of Alzheimer.
What has been the role of pharmacology?
It has been a mistake of science to have launched a "Molecular therapy" in terms of the action of neurotransmitters using inhibitors looking for alleged causes in the action of these, initially p To alleviate the aggressiveness of the patient, a serotonin inhibitor (related to mood) would work, or for anticholinergics, with consequences of disadvantage for the patient, since this neurotransmitter (acetylcholine) has a diversity of functions and is multifaceted ( acts as exciter, receiver) one of its main functions: motor control, activity on the autonomic nervous system, paradoxical sleep (by inhibiting Acetylcholine to the patient hallucinations present), the production and management of hormones, awareness, attention and learning, formation of memories and perception of pain. As a result of the blunder in the formulation of chemical molecules for the management of Alzheimer's disease, they are using a neurotransmitter inhibitor known as Glutamate that has an important function because its excitatory action is related to memory and the remembrances, for this reason The patient who started with a simple distortion of the conscious attention mechanism ends up in a vegetative state, as the biological memories are canceled (walking, eating, losing potty training, sleep, etc.), hence the most "innovative" in medicines for Alzheimer is memantine and concomitant with it, the patient must be given antidepressants. What indicates without fear of making mistakes that this mistake is what has prevented the patient's recovery and is the reason why "medical science" has concluded that only chemical molecules exist to alleviate the symptoms (?) And that Alzheimer, It has no cure.
Therefore, in the case of Alzheimer's disease, "current molecular therapies" can not even be considered as palliative or placebo effects, due to the physiological conditions of the brain at the (functional) amino acid level, nor the psychological conditions of the patient. (It is not in conscious capacity: perception), on the contrary these chemical molecules can be classified as "predatory procedures" because they inhibit the proteins that generate electrical impulses for the good functionality of the brain and therefore the complementary functions of the organism.
What would be the way forward?
To confirm the cause of the destructuring of the prot Amyloid ein is necessary through chemical analysis by titration or by qualitative and quantitative analysis (analytical chemistry), extract a sample of cerebrospinal fluid to confirm if this acid or very alkaline, even though I would lean for a Ph below 7.0 ( Acid), hence in previous publications included Alzheimer as one of the many symptoms of cancer, since cancer occurs when the extracellular fluids of the human body have Ph below 7.0, so it is very important before applying the human hydrobiofisiología to correct these conditions. (See in vocabulary below the human hidrobiofisiología).
After confirmed it proceeds to the appropriate treatment to reestablish the buffer system, this already prevents the destructuring of proteins.
First of all avoid inhibitor use of glutamate (memantine) since it prevents the recovery of the patient, by the functions of this neurotransmitter, that is, this inhibitor does end up leading patients to true Alzheimer until the fatal outcome, remembering that if conservation and reproduction is suppressed, memory is annulled, if the location in the past is suppressed, memory ceases to exist in itself, reiterating again that keepsake is a faculty of memory. Unfortunately for the outcome and suffering of the patient and his relatives, the patient is led to the dark and dark labyrinth of psychiatry. (The relationship between the cranial nerves and the spinal nerves is remembered again.) We can infer that thanks to the neurotransmitter of acetylcholine, although the patient is being supplied with the glutamate inhibitor (memantine), acetylcholine enters to replace the function of this as an emergent mechanism, which is why these neurotransmitters are overloaded, so initially the immediate effects of the glutamate inhibitor are not noticed when suppressing the communications between the cranial and spinal nerves.
It seems the only innovation in terms of " scientific literature "that exists, is the change of expression of the ancient and secular phrase called" charlatanism "by" shamanism "to justify the lack of elements of judgments in terms of procedures applied and irresponsibly endorse their mistakes and academic outbursts.
Taking into account the structure of the brain and its constitution lipid is necessary to supply the patient nootropics, phospholipids, DHA, omega 3, and amino acids necessary for brain function. We will still remember how our ancestors for memory took phytin or neurobasal, with this they showed us with elements of judgment that memory loss is not avoided with mental exercises since ideas and thoughts are chemical reactions of amino acids that are transferred in electrical impulses. The human brain as a chemical and biological battery needs not only the elements (amino acids, proteins, enzymes) to produce the electrical potential, but also needs an adequate electrolytic solution (cerebrospinal fluid under standard electrolytic conditions) so that its components do not deteriorate and work perfectly.
To reflect: The human brain is composed of almost 60% of lipids, so it is not surprising that omega 3 are closely related to the health of this vital organ. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the forms of omega 3 especially important for the maintenance of normal brain function in adults (1). These fats make the cell membranes and promote the formation of new brain cells and contribute to their better functioning and facilitate the bonding of metabolic reactions, increasing their metabolism and producing more energy, as omegas are long chain carboxyls (-COOH) a of its physical properties is its solubility since they are bipolar or amphipathic molecules (from the Greek amphi: double). The heads of the molecule is polar or ionic, therefore hydrophilic (-COOH). The chain is apolar or hydrophobic (terminal groups -CH2- and -CH3). (The α-amino acids of the peptides and proteins (except proline) consist of a carboxylic acid (-COOH) and an amino functional group (-NH2) attached to the same atom of tetrahedral carbon). We could conclude in the hypothesis that fatty acids for their properties and their electronic and molecular configurations enter to solve the problem in a hostile environment (where the mechanism of homeostatic regulation is not found within the cerebrospinal fluid conditions) in the destructuration of the Amyloid and Tau proteins. Peptides, like amino acids and proteins are biomolecules with an amphoteric character that allow the homeostatic regulation of organisms, that is, fatty acids restore homeostasis to stop and correct the denaturation of the proteins Amyloid and Tau when presented this condition. Therefore, it will not be possible to create supposed vaccines to prevent Alzheimer's. (1) Horrocks LA, Yeo YK: Health Benefits of docosahexaenoic acid (DHA). Pharmacol Res. 1999; 40 (3): 211-25. https://www.ncbi.nlm.nih.gov/pubmed/10479465.
Acetylcholine: a neurotransmitter.Acetylcholine is a substance classified as ester, made by compounds of an oxygenated acid and an organic radical, and the different elements which are responsible for its synthesis and elimination form the so-called cholinergic system. Acetylcholine is mainly seen as an excitatory neurotransmitter, but may also exert an inhibitory action depending on the type of synapse in the act. On the other hand, it is considered that the Acetylcholine is one of the main neurotransmitters of the nervous system and one of the most common, being able to be found throughout the entire brain and in the autonomic nervous system.
Amyloid: Amyloid precursor protein. APP is known to be the precursor molecule of β-amyloid, a peptide of 42 amino acids, which is the main component of amyloid plaques present in the brain tissue of patients suffering from Alzheimer's Disease.
Amino Acid: An amino acid is a organic molecule with an amino group (-NH2) and a carboxyl group (-COOH). The most frequent and most interesting amino acids are those that are part of proteins, play a key role in almost all biological processes. Amino acids are the basis of proteins.
Anfótero: In Chemistry, an amphoteric substance is one that can react either as an acid or as a base. The word derives from the Greek prefix amphi- (αμφu-) which means "both". Many metals (such as zinc, tin, lead, aluminum, and beryllium) and most metalloids have amphoteric oxides or hydroxides.
Enzymes: are molecules of a protein nature that catalyze chemical reactions, provided they are thermodynamically possible: an enzyme makes a chemical reaction that is energetically possible, but that takes place at a very low speed, is kinetically favorable, that is, it proceeds at a higher speed than without the presence of the enzyme. In these reactions, the enzymes act on molecules called substrates, which become different molecules called products. Almost all processes in cells require enzymes to occur at significant rates. Enzyme-mediated reactions are called enzymatic reactions.
Fospholipids: Phospholipids are a type of amphipathic lipids composed of an alcohol molecule (glycerol or sphingosine), to which two fatty acids (1,2-diacylglycerol) are attached and a phosphate group.
Glutamate: Glutamate mediates most of the excitatory synapses of the Central Nervous System (CNS). It is the main mediator of sensory, motor, cognitive, emotional information and intervenes in the formation of memories and in their recovery, being present in 80-90% of brain synapses.
R Groups: The most striking feature of amino acids ( AA) is the existence in the same molecule of acid groups (capable of yielding H +) and basic groups (capable of capturing H +). Therefore, in an acid medium they behave as bases, and in a basic medium they behave like acids. The molecules that present this characteristic are said to be amphoteric or ampholytes. The α-amino acids of the peptides and proteins (except proline) consist of a carboxylic acid (-COOH) and an amino functional group (-NH2) attached to the same tetrahedral carbon atom. This carbon is the α-carbon. The R-groups that distinguish one amino acid from another also bind to the α-carbon (except in the case of glycine where the -R groups is hydrogen). The fourth substitution in the carbon-tetrahedral α of the amino acids is hydrogen.
Human Hydrobiology: Expression introduced by José Tejada Maury to refer to the application of physics as a science in the functioning mechanisms of the human body, to make those processes comprehensible and functions of living beings, especially regarding the mechanics of fluids because the human body is constituted in 70% of isotonic seawater. The importance of keeping the liquid part of the organism in optimal conditions in the human body as an irrigation system and as a conductive medium of bioelectricity, maintenance must be carried out (prophylaxis) to prevent the poor quality of body fluids affecting the proper functioning of the cells and therefore of the organs, the density, the viscosity of the blood plasma, as well as the physicochemical conditions of the internal environment, which must necessarily maintain the alkalinity between 7.35 and 7.45 and the body temperature between 36 , 5 and 37 degrees Celsius. Maintenance of filtering and disposal systems such as the intestines, skin, lungs and kidneys. Without neglecting the laboratory of our body as it is the liver which also requires prophylaxis twice a year.
Hydrophobic: In the physicochemical context, the term hydrophobic is applied to those substances that are repelled by water or that can not be mixed with it.1 An example of hydrophobic substances are oils.
Inhibitors: Enzymatic inhibitors are molecules that come together to enzymes and decrease their activity. Well Because blocking an enzyme can kill a pathogen or correct a metabolic imbalance, many drugs act as enzyme inhibitors. They are also used as herbicides and pesticides. However, not all molecules that bind to enzymes are inhibitory; Enzyme activators bind enzymes and increase their activity.
Cerebrospinal Fluid: The function of the cerebrospinal fluid is to protect, feed, lubricate, help the electrical function of the central nervous system, among others. That is, it provides the most appropriate means for the survival and function of the main coordination and communication system of the human body. Both the brain and the spinal cord are the most protected organs of the human body, contained within the framework of the skull and the spine respectively and fortified by a large number of muscles and ligaments. The central nervous system is a semi-closed system guarded by the wonderful mechanism of the hematocephalic barrier, a very specialized tissue, which also thanks to its specific permeability effectively isolates the circulation of the cerebrospinal fluid from other body fluids, such as venous blood, the arterial, the lymph and the extracellular fluid, at the same time that allows an essential and selective communication between them. Lipids: they are a heterogeneous group of organic compounds. Within them are fats, which are divided into saturated and unsaturated. Their chemical structure varies and their properties and functions also depend on the acids they contain. Lipids are a very heterogeneous group of organic compounds, consisting mainly of carbon, hydrogen and oxygen, and sometimes by sulfur, nitrogen and phosphorus. In food there are essentially three types of lipids: ● Fats or oils (also called triglycerides or triacylglycerides) ● Phospholipids ● Cholesterol esters, which show a common component: fatty acids. There are three types: saturated fatty acids (AGS), monounsaturated fatty acids (AGM), polyunsaturated fatty acids (AGP). To remember: 60% of the brain is composed of lipids.
Apolar molecules: Are those molecules that are produced by the union between atoms that have the same electronegativity, so the forces with which the atoms that make up the molecule attract the electrons of the bond that are equal. A molecule is polar when one of its ends is positively charged, and the other negatively. When a molecule is apolar, these charges do not exist.The hydrophobic term is often used for an apolar substance, due to the similarity of behaviors: a hydrophobic is that or that which repels or hates water and apolar substances do not dissolve in water despite being liquid (like oil). Water is a polar solvent, and therefore, it can only harbor polar molecules. This is based on the fact that at microscopic levels, something dissolves in a substance when molecular bridges appear between the solvent and solute particles. These bridges (or intermolecular forces) appear between the zones with different loads in both substances. Water is a polar molecule (it has two zones with different charge, positive and negative) and anything that you want to dissolve in it, must be polar, to be able to establish said links. Neurotransmitter:
A neurotransmitter (neuromediator or chemical messenger): Is a biomolecule that allows neurotransmission, that is, the transmission of information from a neuron (a cell type of the nervous system) to another neuron, a muscle cell or a gland, through the synapse that separates them. The neurotransmitter is released from the synaptic vesicles at the end of the presynaptic neuron, towards the synapse, crosses the synaptic space and acts on the specific cell receptors of the target cell.
Nootropics: Nootropics, also known as smart drugs, stimulants of the Memory and cognitive enhancers are drugs, medicines, drugs, supplements, nutraceuticals or functional foods that elevate certain human mental functions (functions and brain capacities) such as cognition, memory, intelligence, creativity, motivation, attention and concentration. They include peripheral vasodilator substances, vasoactive agents, brain activators, neurotransmitter activators, neuroprotectors, neuroregenerators, neuropeptides, hormones and vitamins. In most cases the mechanism of action of nootropics is unknown. It is believed that nootropics work by altering the availability of neurochemical supplies in the brain (neurotransmitters, enzymes and hormones), by improving or activating brain metabolism, or by stimulating neuronal growth (neurogenesis).
Peptides: Peptides (in Greek: πεπτός [peptós], 'digerido ') are a type of molecules formed by the union of several amino acids by peptide bonds. Peptides, like proteins, are present in nature and are responsible for a large number of functions, many of which are not yet The union of a low number of amino acids gives rise to a peptide, and if the number is high, to a protein, although the limits between both are not defined. Orientative:
Oligopeptide: from 2 to 10 amino acids. Polypeptide: between 10 and 100 amino acids. Protein: more than 100 amino acids. Proteins with a single polypeptide chain are called monomeric proteins, while those composed of more than one polypeptide chain are known as multimeric proteins. Peptides differ from proteins in that they are smaller (have less than 10,000 or 12,000 Daltons of mass) and that the proteins can be formed by the binding of several polypeptides and sometimes prosthetic groups. An example of a polypeptide is insulin, composed of 51 amino acids and known as a hormone according to the function it has in the body of humans.
Chemical precursor: Is an essential or necessary substance to produce another chemical compounds that constitute a first stage in a chemical process and acting as a substrate in later stages.
Prosthetics: A prosthetic group is the non-amino acid component that is part of the structure of heteroproteins or conjugated proteins, being covalently linked to apoprotein.
Proteins: Proteins (
Tau protein: The tau protein, abundant in the central nervous system (CNS) and in the peripheral nervous system (SNP), lies at the neuronal level in the axons Its function is linked to the union of microtubules that in turn are associated with tubulin to stabilize the neuronal cytoskeleton.
Unit of unified atomic mass (symbol «u») or Dalton: (symbol «Da») is a standard unit of mass defined as the twelfth part (1/12) of the mass of an atom, neutral and unlinked, of carbon -12, in its electrical and nuclear ground state, and is equivalent to 1,660 538 921 (73) × 10-27 kg (value recommended by CODATA). The mass of 1 mol of units (NA) of atomic mass equals 1 g. It is used to express the mass of atoms and molecules (atomic mass and molecular mass).
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